Cisco Secure Email Gateway vulnerability: CVE-2026-76461 #

Cisco has reported a vulnerability in their Secure Email Gateway product. This flaw allows remote, unauthenticated attackers to execute arbitrary code on the vulnerable system. Successful exploitation could allow complete system compromise.

This vulnerability has been assigned CVE-2026-76461 and is rated highly critical has a CVSS score of 9.8.

Note that there is evidence that this vulnerability is being actively exploited in the wild.

The following versions are affected

  • 15.5.4-012 and earlier
  • 16.0.3-044 and earlier
  • 16.5.0 before 16.5.0-780

What is Cisco Secure Email Gateway? #

Cisco Secure Email Gateway is a secure email security appliance that allows organizations to handle email securely and potentially quarantine malicious or unwanted emails for analysis.

What is the impact? #

Successful exploitation of these vulnerabilities would allow an adversary to execute arbitrary code on the vulnerable host, potentially leading to complete system compromise.

Are updates or workarounds available? #

Users are encouraged to update to the latest version as quickly as possible:

  • 15.5.5-014 and later
  • 16.0.4-302 and later
  • 16.5.0-780 and later

Find exposed Cisco Secure Email Gateway's with runZero #

From the Service inventory, use the following query to locate potentially vulnerable assets:

_asset.protocol:=http AND protocol:=http AND last.html.title:"Cisco%Gateway%C" AND NOT last.html.title:"Cloud"

December 2025 advisory: #

Cisco reported a vulnerability in their Secure Email Gateway product. This flaw allowed remote, unauthenticated attackers to execute arbitrary code on the vulnerable system. Successful exploitation could have allowed complete system compromise.

This vulnerability was assigned CVE-2025-20393, was rated highly critical, and had a CVSS score of 10.0. 

Note that there was evidence that this vulnerability was being actively exploited in the wild.

All versions of Cisco Secure Email Gateway except Cisco Secure Email Gateway Cloud were affected.

What was the impact? #

Successful exploitation of these vulnerabilities would have allowed an adversary to execute arbitrary code on the vulnerable host, potentially leading to complete system compromise.

Were updates or workarounds available? #

There was no patched fixed version of this product available at the time. The vendor recommended disabling the "Spam Quarantine" feature and isolating potentially vulnerable systems behind network access controls.

How runZero users found potentially vulnerable systems #

From the Service inventory, users ran the following query to locate potentially vulnerable assets:

_asset.protocol:=http AND protocol:=http AND last.html.title:"Cisco%Gateway%C" AND NOT last.html.title:"Cloud"

Written by Rob King

Rob King is the Director of Applied Research at runZero. Over his career Rob has served as a senior researcher with KoreLogic, the architect for TippingPoint DVLabs, and helped get several startups off the ground. Rob helped design SC Magazine's Data Leakage Prevention Product of the Year for 2010, and was awarded the 3Com Innovator of the Year Award in 2009. He has been invited to speak at BlackHat, Shmoocon, SANS Network Security, and USENIX.

More about Rob King

Written by Cale Black

Cale Black is a vulnerability researcher at runZero. Previously Cale worked as a lead penetration tester and researcher where he reproduced and delivered over 200 N-day exploits, and developed for the go-exploit exploitation framework.

More about Cale Black
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